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Description
The GLP-1R/GIPR dual-agonist tirzepatide has demonstrated a remarkable 23% body weight reduction in individuals with obesity over 72 weeks, eclipsing the average result achieved by certain bariatric surgery [78]
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[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Low Wang CC, Everett BM, Burman KD, Wilson PWF

GLP-1R in glutamatergic but not GABAergic neurons was required for this effect (122)

In fact, GLP-1 medications produce some of the largest weight loss results 2 seen with pharmaceutical treatments

Studies suggest smaller, frequent meals can reduce nausea on GLP-1 meds
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