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"The agency's notice today reaffirms that compounding is meant to be a rare and limited exception to FDA's gold-standard drug approval framework," a Novo spokesperson said

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It remains unclear, however, whether such effects mitigate hypoxia risk and ultimately fibrosis and nephron loss as described below

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In Pennsylvania, a $3.5 billion facility in Fogelsville, announced in January 2026 and beginning construction in 2026, will manufacture tirzepatide and next-generation peptides including retatrutide, with completion expected in 2031

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