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an analysis based on the current literature, Front

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[DOI] [PubMed] [Google Scholar] 59.Fulcher G, Matthews DR, Perkovic V, de Zeeuw D, Mahaffey KW, Mathieu C, et al

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Low-dose GLP-1RAs are initiated at the start of treatment and gradually increased to enhance tolerability

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And the TMD is responsible for further interaction with the N-terminus of the ligand, which triggers receptor activation (Ma et al., 2020)

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