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Understanding these dynamics is critical for optimizing the use of GLP-1based agents in disorders with central components, including neurodegeneration, psychiatric illness, and addiction

2025;388:e080679

Rotating the exact location within the abdominal area with each injection can help prevent skin irritation and improve absorption

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4 Challenges and future directions 4.1 Safety considerations The safety profile of dual or triple receptor agonists targeting GLP-1, GIP, and GCG receptors in the treatment of MASLD and related metabolic disorders warrants careful evaluation