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With the exception of California, all of the SBM states are from those regions, as are two of the FFM states (DE and NH)

Regular physical activity supports fat loss, preserves lean muscle mass, and improves overall metabolic outcomes

Moreover, considering the CVD continuum where it progresses from risk factors such as diabetes to atherosclerosis and CHD, until it leads to heart failure or death [46], GLP-1 analogues act in different stages of this pathophysiological process (see Fig

Additionally, the same study reported a decrease in cigarette smoking among participants who were smokers, suggesting potential cross-substance benefits of GLP-1RAs in this population (Hendershot et al., 2025)

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