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Full effects on weight and blood sugar control typically develop over several months of treatment

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Feeling too weak to fight well at age 78, he also discontinued the drug and now relies on other diabetes medications

Future Trials for Retatrutide

Consequent changes in AUC, C max, and T max values of orally administered concomitant medications may occur, which could impact drug efficacy or safety

Strategies could include dosing rapid-acting insulins 30-minutes after the start of eating (instead of the typical 15 minutes before meals), or split-bolus dosing, whereby a patient takes 50% of their rapid acting insulin before a meal, and 50% 30-minutes after the start of a meal