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reduction in actual cardiovascular events has not been proven

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Patients who lose the most weight on GLP-1s tend to make protein-forward food choices, stay hydrated (GLP-1s slow gastric emptying and dehydrate patients faster than they realize), prioritize sleep (sleep deprivation drives weight regain), and add some form of strength training

Like the GHSR1a, the 5-HT 2C serotonin receptor signals through a G q pathway, leading to Ca 2+ accumulation (Schellekens et al., 2013)

R., Kochar N., Agarwal M
