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And their effects can be significant

Patience during dose titration usually pays off

According to NICE guidance , first-line therapy often includes corticosteroids (such as prednisolone or budesonide) for acute flares, alongside immunosuppressants like azathioprine, mercaptopurine, or methotrexate for maintenance

Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions

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