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Both are part of the glucagon-like peptide-1 receptor agonists (GLP-1 RAs) family

Even with discounts and rebates offered by companies like Eli Lilly, the costs are restrictive for a large portion of the necessary population

However, an unphysiologically large postprandial release of GLP1, for example, after gastric bypass surgery (Korner et al., 2007), might reach the circumventricular organs, and DPP4resistant GLP1 receptor agonists clearly have central actions, though whether this includes action on GLP1 receptors inside the BBB or is limited to direct activation of GLP1 receptors in the circumventricular organs outside the BBB, is less clear (Adams et al., 2018

Even with liquid cooling, power costs are nontrivial

In the U.S., about 40% of adults live with obesity

[DOI] [PubMed] [Google Scholar] [124].Scott DA, Boye KS, Timlin L, Clark JF, Best JH, A network meta-analysis to compare glycaemic control in patients with type 2 diabetes treated with exenatide once weekly or liraglutide once daily in comparison with insulin glargine, exenatide twice daily or placebo, Diabetes, obesity & metabolism, 15 (2013) 213223