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comparing cardiovascular and kidney outcomes with tirzepatide vs. glp-1 agonists A comparison of the effects of dulaglutide on major events in people type 2 diabetes: pre-specified exploratory analyses of the SURPASS-CVOT trial GLP-1 receptor agonists and next-generation
Description
F.LingvayI.et al (2021)
The expression of pre-proglucagon gene and GLP-1 has been detected in the human brainstem and hypothalamus (140)
Effects of age, sex, and treatment on weight-loss dynamics in overweight people
HR 0.88
However, prolonged exposure to GLP-1RAs can lead to tachyphylaxis, reducing their effect on gastric emptying over time
As the SELECT trial nears completion, a similar large trial was launched in autumn 2022, but this one involves a new wrinkle on GLP-1 receptor agonism that appears to yield even greater weight loss
