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Study that gives important insight into the molecular mode of action of GLP-1 by identifying the cellular localization of GLP-1R in monkey and human tissue using the most extensively validated monoclonal antibody to date

Funding Statement This research was supported by Fundacion CardioInfantil IC and Universidad del Rosario

GLP-1 producing neurons in the brainstem are activated following a large satiating meal suggesting that these neurons relay satiety signals to higher brain regions (Kreisler et al., 2014)

In consideration of the multiple metabolic and cardiovascular effects seen in subjects treated with GLP-1RAs and SGLT-2is (e.g., reduction of hyperglycemia, weight loss, free/fat mass and bone remodeling, anti-atherosclerosis, natriuresis), it is reasonable to speculate that GH and IGF-1 may play a about a relevant role in this context

This is done with diet and weight training