glp-1 heart disease receptor agonists (GLP-1RAs): cardiovascular actions and therapeutic potential Comprehensive Overview of GLP-1 RAs

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While a number of mechanisms including vascular, myocardial, renal, and central nervous system pathways have been suggested in animal studies, these mechanistic pathways have not been sufficiently detailed in humans and it is unclear if the same pathways are operational

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20251222(FDA)(GLP-1)Novo NordiskWegovy

Composite kidney events were reported in 134 (38.2%) and 393 (44.2%) patients in the GLP-1RA and DPP-4i groups, respectively (subdistribution HR 0.72, 95% CI 0.560.93)