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According to the researchers, in addition to weight loss, only one flare was reported

In the SUSTAIN 8 study, patients with T2DM exhibited a lean mass decrease of 2.3 kg alongside a total weight loss of 5.3 kg, resulting in 43.4% of weight loss attributable to lean mass, while the ratio of lean mass to total mass increased by 1.2% from the baseline [111]

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Lund PK, Goodman RH, Habener JF

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doi: 10.1172/JCI141828