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(2024) Jun 17 [cited 2025 Jul 16] 25.McEvoy RD, Antic NA, Heeley E et al (2016) CPAP for prevention of cardiovascular events in obstructive sleep apnea

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These are manageable with dose titration, but they drive roughly half of early discontinuations

Patients who experience substantial weight loss or excellent glycemic control with minimal side effects are more likely to continue long-term therapy

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Modern incretin-based therapy still relies heavily on appetite suppression, but the addition of glucagon receptor activation may shift the model toward a broader metabolic strategy: reducing food intake while increasing energy expenditure and improving hepatic lipid metabolism
