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GLP-1s and Addiction The authors of GLP-1 Therapeutics and Their Emerging Role in Alcohol and Substance Use Disorders: An Endocrinology Primer , appearing in October 2025 in JES, point out that the World Health Organization reported 890 million adults and 60 million children and adolescents had obesity in 2022 globally

While semaglutide was originally created as a diabetes drug, the use of semaglutide for weight loss in patients with diabetes should be managed by an endocrinologist

Genetic Factors and Individual Response Variability Emerging evidence suggests genetic variants in GLP-1 receptor, GIPR, FTO, and MC4R genes contribute to individual differences in weight loss response and appetite regulation