glp-1 small molecule agonist A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency GLP-1 Receptor Agonists as Treatments

The most common side effects for all agents in this drug class are nasopharyngitis, headache, and upper respiratory tract infection

*Correspondence: Elisabet Jerlhag, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

10.17219/acem/151695 [DOI] [PubMed] [Google Scholar] 22

The Wall Street Journal

Potential Side Effects The GLP-1 receptor agonists type medications interfere with absorption and utilization of vitamins and minerals in the body which may lead to nutrient depletion, loss of muscle mass and changes in facial appearance

Nonetheless, mice deficient for GRP have impaired glucose tolerance, reduced first-phase insulin secretion and impaired GLP-1 secretion in response to an oral glucose challenge [343]