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Tirzepatide Research on naturally occurring incretins isolated from some fish (e.g., lamprey, dogfish and paddlefish) has shown that they can act as dual agonist of the GLP-1, GIP, and glucagon receptors, to lower blood glucose levels and induce weight loss (reviewed in Conlon et al., 2022)

Use of GLP-1 RAs is limited by high cost, which creates disparities those who cannot afford these drugs may miss out on the benefits

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