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Although medications for diabetes mellitus have been updated and evolved in recent years, it is not clear whether the use of these drugs in patients with diabetes induces DR, therefore, it is especially crucial to thoroughly examine the safety of these drugs

Other evidence also suggests that GLP-1R in the cerebral cortex affects hedonic feeding by targeting areas involved in reward and addiction (110)

What the published research reported A phase-2 randomized trial published in the New England Journal of Medicine in 2023 studied retatrutide in adults with obesity and reported substantial, dose-dependent reductions in body weight over 48 weeks, alongside a gastrointestinal side-effect profile broadly similar to other incretin drugs

Pharmacotherapy for gestational diabetes

Efficacy and weight loss outcomes Clinical trials demonstrate distinct results: Zepbound : Participants lost 20.2% of body weight on average (50.3 lbs) over 72 weeks in SURMOUNT-5 trials

The activation of GLP-1 receptors has become a focus in the search for effective treatments for diabetes and metabolic disorders, and it has more recently gained approval as a weight-loss treatment