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For example, people with the GLP1R rs6923761 variant show different dose-response patterns than those without it, suggesting that genetic screening could identify who benefits most from standard doses versus those needing personalized adjustment

However, modest increases in resting heart rate consistently appear across GLP-1 trials, typically averaging 2 to 4 beats per minute

As a result, there has been a recent movement to create and use analogues that manipulate these gut hormones to support weight loss

Most patients navigate GLP-1 therapy without cardiac complications when they understand what normal adaptation looks like

I have no desire to drink alcohol and my food cravings have gone away, Kirtley said