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Once they cracked the problem, scientists got creative

Love Employee stock.adobe.com News Study finds faster regain than ending diet programmes GLP-1 discontinuation: weight-loss drugs work until you stop Research sounds a cautionary note for short-term use without a more comprehensive approach to weight management People tend to regain weight rapidly after stopping weight-loss drugs - and faster than after ending behavioural weight loss programmes - according to a new systematic review and meta-analysis from researchers in Oxford's Nuffield Department of Primary Care Health Sciences, published in The BMJ

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These include GI side effects

The cardioprotective and survival advantages of liraglutide were superior to those of metformin in both normal and diabetic mice and were independent of weight loss (Noyan-Ashraf et al