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Preliminary analysis detected no difference in beta diversity between baseline versus post-treatment ( Supplementary Figure 4 ) and distinct microbial features between two drug users ( Supplementary Figure 5 ), but more data are needed for further interpretation

This inhibits the activation of intestinal FXR signaling, thereby facilitating enhanced glucose homeostasis ( Changes in the gut microbiota caused by metformin are crucial for its ability to reduce inflammation

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Experimental observations also show delayed gastric emptying consistent with GLP-1 receptor signaling, although this effect may diminish over extended observation periods in some research models

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