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The SEMALEAN study provides important real-world evidence on the effects of semaglutide 2.4 mg over 12 months in patients with severe obesity (mean BMI 46.3 kg/m)

6,7 Recent investigations have revealed that GLP 1 RAs possess the ability to suppress the PI3K/AKT/ mTOR and ERK/MAPK pathways, resulting in the suppression of prostate cancer growth

Additionally, pulmonary venous hypertension can directly cause venous endothelial damage [78]
