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2023 doi: 10.1097/hep.0000000000000598

Its kind of a learned helplessness paradigm

Evidence from Research and Social Media Data A study by Tveit et al
Fatigue : Some individuals report feeling more tired than usual, particularly during the first few weeks of treatment
doi: 10.1038/ijo.2015.172 17 DeaconCFHolstJJ

Weight loss induced by these agents may also contribute to symptom improvement by reducing mechanical stress in intertriginous areas and mitigating inflammatory responses associated with HS