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The FDA signaled escalating enforcement, and on April 30, 2026, it proposed excluding semaglutide, tirzepatide, and liraglutide from the 503B outsourcing facility bulks list - the mechanism that governs which substances large-scale compounders may use - with a public comment period open through June 29, 2026

For example, some programs have demonstrated that members who dont take GLP-1s but do engage in intensive lifestyle modification still achieve significant weight loss (around 9% loss after one year, according to data from one of our partners)

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PlexusDx compounded semaglutide therapy is designed to support your long-term health, and open communication with your prescribing physician ensures safe concurrent use of any pain relief medications

Ding X, Saxena NK, Lin S, Gupta NA, Anania FA