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These combined effects lead to improved glycemic control in patients with diabetes and significant weight reduction in both diabetic and non-diabetic individuals

Conversely, those with diarrhoea should ensure adequate fluid and electrolyte replacement to prevent dehydration

It can, especially during the early stages of treatment

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This intensification can lead to discomfort, dehydration, and potentially impact adherence to both treatments

However, no published switching study in an obesity population has directly measured weight loss outcomes following a semaglutide-to-tirzepatide transition