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Using male C57BL/6 mice, the authors evaluated the effects of Ex4 (2.4 g/kg, i.p.) on morphine-induced CPP, locomotor sensitization, and analgesic tolerance

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These studies indicate that the amount of WL may vary in real-world data compared to clinical trials [66]

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The starting dose of 2.5mg is deliberately low, designed primarily for tolerability rather than therapeutic effect

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