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This evidence reassures patients that the medication itself does not worsen COVID-19 severity or create unique viral complications

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In studies with rodents, tirzepatide caused thyroid tumors, including thyroid cancer

Weight loss reduces the mechanical load on bones, which can lead to lower bone density and, in some people such as those who are postmenopausal, as well as people over age 65 an increased risk of fracture

Notably, GRP regulation of glucose handling is not fully dependent on GLP-1 signaling, because GRP also directly stimulates insulin secretion in the isolated perfused dog pancreas [340] and further delays gastric emptying [341,342]

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