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Because we included adults aged 18 to 65 years without other chronic diseases, the results may not be generalizable to patients with diabetes or older individuals (ie, populations at increased risk of bone fractures)

18 For those patients not achieving desired glycemic control at 1.2 mg, the dose can be increased to 1.8 mg

Metformin addresses insulin resistance through hepatic glucose production inhibition, while semaglutide enhances insulin secretion and reduces appetitetwo distinct mechanisms targeting type 2 diabetes pathophysiology

Int J Mol Sci 26(21):10248

has expressed disdain for the drug, will decide if it stays there

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