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In participants with obesity or overweight, withdrawing tirzepatide led to substantial regain of lost weight, whereas continued treatment maintained and augmented initial weight reduction [75]

[92] [93] Brazil [edit] In Brazil, the supreme court refused to extend semaglutide's patent protection, which expired in March 2026

Storgaard, H., Cold, F., Gluud, L

Piya MK, McTernan PG, Kumar S

That marked a 6% increase, outpacing both inflation and wage growth

Similarly, a previous large-scale clinical trial (SUSTAIN-6) also indicated that the use of GLP-1RAs was associated with an increased risk of DR compared to the placebo group [39], but this result was based on 3,297 T2D patients from 20 countries, and 83.0% of the patients included in the trial already had cardiovascular disease or chronic kidney disease, indicating that the patient population had a high risk of complications