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Metabolic alterations have been studied in the myocardium of heart failure (HF) patients
Mean TTR decreased by 2.1% (95% CI, -3.7% to -0.6%

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), initially developed for the treatment of type 2 diabetes and obesity, may modulate pathways associated with the hallmarks of aging

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