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A useful way to put it: obesity happens when normal people do normal things in an abnormal environment

23 Meal intake triggers the release of GLP-1 from L cells in the distal jejunum, ileum, and colon

Therefore, in most cases, we no longer make comparisons between plan types

doi: 10.1016/S0140-6736(21)00536-5 3

For orforglipron, participants initiated on higher doses and those on rapid titration schemes appeared to have higher discontinuation rates, providing insights into the optimisation process for the phase 3 trials

Any consideration of investigational approaches should occur only within the context of clinical trials or with explicit acknowledgment of the limited evidence base and careful risk-benefit assessment tailored to your specific clinical circumstances