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44,45 Differences in tolerability may be related to dosing frequency, pharmacokinetic profiles, and receptor selectivity, underscoring the importance of individualized dose escalation and careful monitoring in routine clinical practice

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This adaptive thermogenesis makes weight maintenance progressively more difficult and contributes to the high rates of weight regain seen after most interventions

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Keywords: glucagon-like peptide-1 (GLP-1), glucagon-like peptide-1 receptor (GLP-1R), glucagon-like peptide-1 receptor agonist (GLP-1RA), glycogen, glycogenesis, thermogenesis, metabolism 1