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Eligible publications included systematic reviews, meta-analyses, randomized controlled trials, observational studies (cohort, cross-sectional, case-control), and case series

A systematic literature review-based hypothesis

Fatigue and low energy Fatigue in the first few weeks usually comes from a combination of reduced calorie intake and reduced fluid intake happening at the same time

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Benaiges D, Flores Le-Roux JA, Pedro-Botet J, Chillarn JJ, Renard M, Parri A, Ramn JM, Pera M, Goday A

16 During normal muscle physiology at rest, ion channels (including Na + /K + pumps and Na + /Ca 2+ exchangers) located on the plasma membrane (sarcolemma) maintain low intracellular Na + and Ca 2+ concentrations and high K + concentrations within the muscle fiber