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Many clients begin to notice improvements in skin firmness and contour within a few weeks of their first treatment, with continued enhancement over the following months

Less severe but still problematic gastrointestinal reactions warrant dose holds and systematic side effect management

Changes in insulin or Cpeptide can reflect reduced insulin demand as glycemia improves, which is why those values are interpreted alongside symptoms and timing rather than taken alone

Last reviewed: June 22, 2026 Last updated: June 22, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Another option is a standard 12V car cooler or mini fridge

These effects were paralleled by electrophysiological data showing decreased firing rates of VTA dopamine neurons