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Serotonin is responsible for the regulation of mood, memory, sleep, and appetite

CVS/MedImpact, regional Blues PBMs) have analogous policies: standard BMI thresholds, diet/exercise verification, and often a requirement to try older weight-loss drugs (like phentermine or orlistat) before GLP-1 coverage

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The first enrolled patients with obesity and confirmed or suspected POMC or PCSK1 deficiency, while the second enrolled patients with confirmed or suspected LEPR deficiency

Dose escalation awareness is crucial for prevention

SGLT2 inhibitor users had the highest rates of hypertension and cardiovascular disease, whereas women prescribed GLP-1R agonists were more likely to be obese or suffer from polycystic ovarian syndrome (PCOS)