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Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the -cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus
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These actions have been clinically exploited by the development of amylin and GLP-1 hormone analogs now used for treatment of diabetes and obesity

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