hydration effects glp-1 receptor agonist therapy 2025 How Much Water a Day on GLP-1: Guidelines Metabolic Flux Adaptations During GLP-1

doi: 10.1016/S0140-6736(87)91194-9 22 HolstJJ

GH reports research grants from the Netherlands Organization for Scientific Research (vidi 016.156.445), CardioVascular Research Initiative, European Union and the Klinkerpad fonds, institutional research support from Aegerion, Amgen, AstraZeneca, Eli Lilly, Genzyme, Ionis, Kowa, Pfizer, Regeneron, Roche, Sanofi, and The Medicines Company

PubMed CrossRef Carmellini P, Cuomo A, Rescalli MB, et al

For 2,567 semaglutide users who stopped treatment, 33% regained weight, 32% maintained weight loss, and 35% continued losing weight

In a systematic review of 55 double-blinded, placebo-controlled randomized clinical trials, GLP-1RA treatment was associated with an increased risk of cholelithiasis compared with placebo (RR 1.46, 95% CI 1.091.97) but not cholecystitis, cholangitis, or pancreatitis (63)

Back Edwards, K, Li, X, Linvay, I (1 April 2023) 'Clinical and safety outcomes with GLP-1 receptor agonists and SGLT2 inhibitors in type 1 diabetes: A real-world study', The Journal of Clinical Endocrinology & Metabolism , 108/ 4, 92030