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The ADA 2026 Standards of Care now recommend GLP-1 receptor agonists with demonstrated cardiovascular benefit for patients with type 2 diabetes and established ASCVD, multiple cardiovascular risk factors, or chronic kidney disease, and note that combination with SGLT2 inhibitors may provide additive benefit

Conversely, IR contributes to reduced dopamine transporter expression coupled with increased excitatory glutamatergic input, elevating extracellular dopamine levels

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Because these symptoms can occur with daily activities speaking, breathing and swallowing they can affect daily life

The primary endpoints are alteration of transcriptomic profile of tongue tissue as changes in expression level from baseline to follow-up after 16 weeks of treatment, measured by RNA sequencing, and change in taste sensitivity as detected by chemical gustometry