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All covariates were binary, categorical, or continuous but were essentially guaranteed to exist (more details on TriNetX are in the eAppendix in Supplement 1)
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In PIONEER 5, mean weight loss was -3.5% with semaglutide 14 mg versus -0.9% with placebo from baseline to week 26
Candidates should be open to collaborating with a healthcare provider on dosing, side effects, and lifestyle support
