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hCG concentration is measured in urine, and while modern tests are incredibly sensitive, a severely diluted sample can lower the concentration of hCG below the test's detection threshold, resulting in a false negative

The PGIS for Physical Activity is a participant-rated assessment of current limitations on physical activity due to health and is rated on a 5-point scale ranging from not at all limited to extremely limited. Responses to the PGIS for Physical Activity were used to identify participants with moderately, very, or extremely limited physical function at baseline

Zepbound was removed from Standard, Advanced Control, and Value formularies on July 1, 2025, affecting an estimated 200,000 patients

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Clinical trial participants who took Zepbound lost an average of 50 pounds over 72 weeks, while those who took semaglutide, or Wegovy, lost about 33 pounds