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Treatment intensification should be considered when HbA1c rises to 58 mmol/mol (7.5%) or higher on lifestyle interventions and metformin, though individualised targets may be appropriate

Cagrilintide is a long-acting acylated analogue of amylin, a hormone co-secreted with insulin that regulates appetite and gastric emptying

Bone health: calcium and vitamin D Rapid weight loss is one of the recognised risk factors for bone loss, and the Wegovy product information lists hip fracture as a rare adverse reaction in SELECT

While one medication has been approved in the US, management of fatty liver disease still largely relies on lifestyle changes such as weight loss and exercise, but GLP-1 agonists show promise

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