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Cardiometabolic Improvements Weight loss was accompanied by clinically meaningful improvements across several cardiovascular risk markers, including reductions in: Waist circumference (mean reduction of approximately 24.1 cm at the highest dose) Non-HDL cholesterol Triglycerides Systolic blood pressure High-sensitivity C-reactive protein (hsCRP) a marker of inflammation These findings are particularly relevant for patients with obesity who also live with cardiometabolic conditions, where systemic risk reduction is as important as the weight loss itself

The FDA reportedly contacted the manufacturer suggesting that the drug had not been marketed in a truthful and non-misleading way

Cox proportional hazards models were employed to estimate hazard ratios (HRs) for each outcome 27

It reduces HbA1c by approximately 1.5-2.0 percentage points in diabetic populations, which is clinically excellent

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