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Incretins are gut secreted hormones, G-protein-coupled receptor peptides, that include glucagon-like peptide 1 (GLP-1), gastric inhibitory polypeptide (GIP) and glucagon (GCG)

For older adults (aged 65 years), the WHO recommends varied multicomponent physical activity, with a focus on balance and strength training, of at least moderate intensity on three or more days each week [115]

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Moreover, the medial prefrontal cortex has been shown to project to 5-HT DRN neurons, and stimulation of this circuit using optogenetics in rats has a profound effect on depression-like behavior [81]

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