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explored the beta-cell protective capacity of this increase in alpha-cell GLP-1 production and found that the xenotransplant of PC1/3-expressing alpha-cells into STZ-treated mice improved glucose tolerance and preserved beta-cell mass in a GLP-1R-dependent manner (56)

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In a Phase 2a substudy published in Nature Medicine, retatrutide at the 12mg dose reduced liver fat by an average of 82.4% from baseline at 24 weeks

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