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Assessing the plot, the excess hazard was initially negative (significantly so), but temporarily increased towards zero after around four to six years of exposure, after which it declined once more

As agents such as semaglutide (Ozempic, Wegovy), tirzepatide (Mounjaro, Zepbound), and liraglutide (Victoza, Saxenda) continue to deliver robust A1C reduction and double-digit weight loss, clinicians must balance metabolic gains with careful risk assessment

In addition, tirzepatide, even at the lowest maintenance dose of 5 mg, can reduce body weight to a greater extent compared with GLP-1 RAs including subcutaneous semaglutide which, in turn, has been shown to be superior to other glucose-lowering agents [28]

1 These lab-made versions bind to GLP-1 receptors in various parts of the body, triggering several effects beneficial for weight loss and metabolic health

Check the prescribing information for your specific medication and talk with your healthcare provider

doi: 10.1182/blood-2012-05-423186