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295 milliosmoles/L) containing (in mM): 138 NaCl, 5.6 KCl, 2.6 CaCl 2 , 1.2 MgCl 2 , 10 HEPES (adjusted to pH 7.4 with NaOH), and supplemented with 11.1 mM glucose, 20 l ml 1 FBS, 1 l ml 1 Pluronic F-127, and 1 M fura-2 acetoxymethyl ester (fura 2-AM

The trial product estimand assesses treatment effect assuming all participants adhered to treatment and did not receive rescue intervention

Accepted by CDE On May 30, the active pharmaceutical ingredient (API) of semaglutide (chemically synthesized), independently developed by our company, was formally accepted by the Center for Drug Evaluation (CDE) of the National Medical Products Administration (NMPA) under the classification of Chemical Drug Category 2.2 (Acceptance No.: CXHL2560002

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