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Description
Both overeating and excessive drinking are mediated by the mesolimbic dopamine pathway the brains reward circuit

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Lee MMY, Ghouri N, McGuire DK, Rutter MK, Sattar N

However, GLP-1 RAs may disrupt this safety margin

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With many of these pathological processes occurring before the development of clinical symptoms, these agents have the potential to exert their influence in the asymptomatic phase of neurodegenerative disease, but would require further evaluation in preventing neurodegeneration and dementia
