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Exercise alone led to similar weight loss as liraglutide alone but with increased lean mass and preserved hip and spine BMD

Chia or ground flax in small amounts: helpful if you tolerate them, but they're not ideal if they worsen nausea

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Accessed March 4, 2026

Older adults with genetic predispositions toward insulin resistance may benefit from tirzepatide's dual-receptor action, while younger patients with specific GLP1R profiles might respond exceptionally well to semaglutide alone

Practical Steps to Combine These Treatments Safely If you are currently on testosterone and considering semaglutide, schedule a comprehensive visit with your primary care provider or endocrinologist to review your full medical history, current medications, and baseline metabolic labs