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How Oral Semaglutide Works to Promote Weight Loss Weight loss with oral semaglutide occurs through a coordinated, multi-stage biological process

(June 2017)

In 2022, citing shortages of the drugs, the FDA allowed compounding pharmacies to make them but with the shortages over, the FDA stopped allowing compounding pharmacies to make tirzepatide (Mounjaro and Zepbound) in March, and semaglutide (Ozempic and Wegovy) last week

The FDA gave small pharmacies until February 18 to stop making tirzepatide, while larger outsourcing facilities had until March 19

Ozempic edges ahead for patients prioritizing maximum A1C reduction and weight loss, while Trulicity appeals to those wanting dosing flexibility and injection simplicity

For patients who want to transition from a compounded product to an FDA-approved one, both clinicians cautioned that the process isnt always straightforward, as it may not be clear what dose a patient on a compounded product had been taking