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however, their use is limited due to the development of intolerable anticholinergic adverse events, including confusion, drowsiness, memory impairment, dry mouth, constipation, and visual changes

And from the data we currently have, it seems to be true

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Participants in tirzepatide groups had statistically significant mean reductions in HbA1c from baseline compared with those in the dulaglutide group, which began at week 4, were near the maximum around week 24, and were maintained until week 52

29,54 The STEP-HFpEF trial reported a reduction in systolic BP by an average of 4.9 mmHg in the semaglutide group, compared to a reduction of 2.0 mmHg in the placebo group, in a mean difference of 2.9 mmHg